Parkinson’s disease in the intestine begins?
Also in the case of Parkinson’s disease, the cause could lie in the gut
Parkinson’s disease is similar to Alzheimer’s disease – a neurodegenerative disease. It concerns worldwide about 4 million people and usually occurs from the age of 60. Since the age of. In Germany and Switzerland, approximately 250,000 to 280,000 of the Affected people have to live together.
In the case of the disease there is a progressive loss of nerve cells in the brain. The typical symptoms include: muscle tremors, rigid muscles, slowed movement, and unstable posture. In conventional medicine, the disease is considered incurable. Specific causes of you don’t know yet.
In a study in the December 2018 in the Journal of Parkinson’s Disease was published, verified to the corresponding researcher, to what extent the gut in the pathogenesis of Parkinson’s disease be involved.
Intestinal health in diagnosis and treatment involve!
You would be aware of the intestine in the diagnosis and treatment of Parkinson’s disease, could not detect the disease only faster, but also to slow down its progression – presumed to be the author of the study, Dr. Filip Scheperjans from the neurological Department of the University clinic in Helsinki, Finland. Because some people suffer for years of stomach-intestinal complaints, before the typical Parkinson’s symptoms such as the muscle tremor of the show of hands.
You diagnosed the disease, however, only then, are most of the Parkinson’s disease affected nerve cells in the brain died, what complicates the treatment significantly. In these cases, it is very difficult to slow down the progression of the disease. Therefore, the research of Parkinson’s scientists aim new methods, to be able to the disease as early as possible to determine – and the bowel is here with some of the researchers are clearly in focus.
The Hiking morbid deposits from the gut to the brain?
More and more studies suggest that Parkinson’s actually starts in the digestive system – at least in the case of those Affected, who had for many years prior to diagnosis digestive disorders. In March 2017, researchers said in a study that Parkinson’s typical deposits in the brain – the so-called Alpha-Synuclein, a Protein that allows nerve cells to die – can migrate via the vagus nerve from the brain to the stomach.
However, some scientists suspect that the deposits take the opposite path, so that the Alpha could Synuclein may with food in the digestive system and from there into the brain wander. We reported here already about it and also the medical journal wrote in January 2017 on this uncertainty, where you look at a study from October 2015, of Mulak and Bonaz refers to the in the World Journal of Gastroenterology published.
The talk of a pathologically permeable intestinal mucosa (Leaky gut syndrome), which stimulates together with a dysbiosis (disrupted bowel flora), the immune system excessively, and then chronic inflammation, and hyperactivity of the nerve cells with subsequent Alpha-Synuclein-education could.
Leaky gut syndrome, intestinal flora disturbances, and inflammation in Parkinson’s disease
In the new above-mentioned Review by December 2018, Dr. Scheperjans said that, at least in a subset of patients, the origin of Parkinson’s disease in the gut could be involved in the Alpha-Synuclein deposits, local inflammatory processes and the intestinal flora. Scheperjans summarized the findings of his team as follows:
- Since Alpha-Synuclein deposits in the nervous system of the digestive system, now needs to be specifically explored whether these deposits are actually with those in the brain are identical.
- The excessive permeability of the intestinal mucosa (Leaky gut syndrome) seems to trigger the Alpha-Synuclein deposits in the intestinal. It must therefore now be examined whether Parkinson’s patients and, if so, to what extent is actually a Leaky gut syndrome.
- So far, the so-called immunohistochemistry as a method for the localization of Alpha-Synuclein deposits was used, but with inconsistent results, so new methods must be developed to achieve more accurate results.
- Large clinical studies with Parkinson’s patients would be required in order to thoroughly explore the mechanisms that could be behind the influence of the intestine on the pathogenesis of Parkinson’s disease. Is imperative that the composition of the intestinal flora of the individual patient, should be studied before and after a Parkinso-diagnosis.
Future Parkinson’s treatment: diet, probiotics, and prebiotics
The Finnish scientists around Scheperjans are in any case sure that the intestinal flora will play in the next decades, an important role in the development of new Parkinson’s disease therapies. Forms of this therapy, dietary changes, the use of probiotics and prebiotics, as well as stool transplants.
“In the last few years we have discovered the importance of the gut-brain connection associated with Parkinson’s disease,” Scheperjans. And Dr. Patrik Brundin, the editor-in-chief of the Journal of Parkinson’s Disease , commented:
“The colon is now in the focus of Parkinson’s research. We are sure that there will be in the next 20 years an enormous progress. Because changes in the intestinal health and can help to diagnose Parkinson’s earlier, during therapies, the affect of these changes can slow down the disease. This includes simple “measures, such as fixing a present chronic constipation, and the General improvement of the intestinal functions”.“
Gut renovation, Parkinson’s disease prevent?
Many of the helpful measures for the improvement of intestinal health, you will find on our pages, whether it is the remedy for chronic constipation, the restoration of the intestinal flora, high-quality probiotics, helpful prebiotics or switching to a bowel healthy diet. Because even if the science is here, still need a few years to gain clarity, it can be nevertheless a long time ago with the above-mentioned naturopathic measures active.